Endocrine Abstracts

Thyroid hormone exerts direct effects on almost every body organ or tissue, and thyroid deficiency produces a wide range of metabolic disturbances. Hypothyroidism is readily recognized in an individual presenting with characteristic clinical signs and symptoms. However involvement of the haematologic and renal systems is less commonly acknowledged making the diagnosis less apparent and, therefore, the initial focus of attention is on a diagnosis other than hypothyroidism.<...

We identified 65 patients from the departmental endocrine database who had received testosterone (T) therapy. 62 records were reviewed and 7 patients excluded as they received T <6 months. We undertook a retrospective audit examining the routine monitoring of these patients. These 55 patients included; 21 patients with primary hypogonadism (PH) and 34 patients with secondary hypogonadism (SH); mean age (range) 52 (28–75) and 59 (35–91) yrs respectively. 46 (84%) ...

Adrenal incidentaloma is a clinically silent adrenal mass detected on imaging performed for unrelated reasons. The concern is whether the incidentaloma is malignant or hypersecreting. The most comprehensive existing guidelines on investigation and management come from NIH Consensus Development Programme.We aimed to determine how many are identified by radiology over 12 months; how many of these are referred to endocrinology; how many are appropriately in...

: The management of endogenous subclinical hyperthyroidism is largely guided by perceived risk, including the presence of cardiovascular disease, atrial fibrillation or osteoporosis. We have utilised a fourth-generation TSH assay, providing a 10-fold increase in sensitivity compared to third-generation assays, to determine whether patients with subclinical hyperthyroidism can be differentiated from those with overt hyperthyroidism, based on their now measurable TSH levels. Two...

Epidemiological studies suggest that hypovitaminosis D is common in patients with primary hyperparathyroidism (PHPT). They have higher levels of serum parathyroid hormone (PTH) and markers of bone turnover, and more frequent fractures than vitamin D replete patients. There are concerns that vitamin D repletion in these patients might exacerbate pre-existent hypercalcaemia, although recent literature suggests this is uncommon.We aimed to determine the eff...

There is a relative lack of data regarding the timing and in particular the severity of hypothyroidism post Radioiodine (RI). We retrospectively examined the timing and severity of hypothyroidism following RI in 213 patients, in relation to ‘target’ and actual follow up appointments, and the introduction of a nurse-led follow-up clinic. Hypothyroidism was defined as persistent elevation of TSH – mild (TSH 6.1–10 mU/l), moderate (TSH 10.1–50 mU/l) and s...